It is to be noted that an error of 1 deg C during the sterilization process ( at 121 deg C) changes the Fo value by 26%. So it is important to use reliable and high accurate sensors with proper fittings for the process technology development and regular monitoring applications. It is also important to mount the measuring needles exactly at the cold spots of the containers for heat penetration studies and regular process monitoring applications.

H.P Studies are designed to determine the precise processing technology of a particular product in a particular container. The worst case scenario needs to be simulated during the studies and confirm that the products would be safe during the processing even in the adverse processing conditions